Duloxetine: MedlinePlus Drug Information

No reports involved the administration of methylene blue by other routes (such as oral tablets or local tissue injection). If it is necessary to initiate treatment with an MAOI such as linezolid or intravenous methylene blue in a patient taking CYMBALTA, discontinue CYMBALTA before initiating treatment with the MAOI [see CONTRAINDICATIONS and DRUG INTERACTIONS]. Cases of cholestatic jaundice with minimal elevation of transaminase levels have also been reported. Other postmarketing reports indicate that elevated transaminases, bilirubin, and alkaline phosphatase have occurred in patients with chronic liver disease or cirrhosis. Results of in vitro studies demonstrate that duloxetine does not inhibit or induce CYP3A activity.

1. These lists contain examples of serious side effects that can occur with Cymbalta, with Lexapro, or with both drugs (when taken individually).
2. Because it affects your mood, some people report feeling calm or having their mood boosted while taking the drug.
3. In many cases, this hyponatremia appears to be the result of the syndrome of inappropriate antidiuretic hormone secretion (SIADH).
4. The researchers looked at 41 clinical trials involving a total of 11 antidepressants, including Cymbalta and Lexapro.
5. With this condition, you may feel sadness, loss, or anger that interferes with your daily activities.

Dosage questions

The recommended starting dosage in adults with MDD is 40 mg/day (given as 20 mg twice daily) to 60 mg/day (given either once daily or as 30 mg twice daily). For some patients, it may be desirable to start at 30 mg once daily for 1 week, to allow patients to adjust to CYMBALTA before increasing to 60 mg once daily. While a 120 mg/day dose was shown to be effective, there is no evidence that doses greater than 60 mg/day confer any additional benefits.

What do I need to tell my doctor BEFORE I take Duloxetine Capsules?

Certain medications inhibit (slow down) the activity of two enzymes, called CYP1A2 and CYP2D6. Taking Cymbalta with these drugs https://soberhome.net/ambien-is-dependence-a-concern/ may increase Cymbalta levels in your body. If you’re interested in finding an alternative to Cymbalta, talk with your doctor.

Depression Quiz: Signs & Symptoms

As suicidal ideation and behavior in clinical trials are rare, the results for any drug taken separately usually do not reach statistical significance. In this meta-analysis, researchers looked at 16 clinical trials comparing Cymbalta with other antidepressants, including three studies that compared Cymbalta with Effexor XR. The researchers found the two drugs to be similarly effective for treating depression. In this meta-analysis, researchers looked at 16 different clinical trials that compared Cymbalta to other antidepressants, including three studies that compared Cymbalta with Lexapro. For major depressive disorder and generalized anxiety disorder, the maximum daily dose of duloxetine oral capsules in 120 mg.

Before taking Cymbalta, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information drug addiction blog and resources can help you avoid potential interactions. Clinical trials have shown Cymbalta to be effective for treating musculoskeletal pain. Clinical trials have shown Cymbalta to be effective for treating fibromyalgia.

Duloxetine oral capsule brand-name versions

Talk to your child’s doctor about the risks of giving duloxetine to your child. Read the Medication Guide and, if available, the Instructions for Use provided by your pharmacist before you start using duloxetine and each time you get a refill. Side effects in adults may also occur in children and adolescents who take Cymbalta.

But if you think you’re having a medical emergency, call 911 or your local emergency number. It’s important to note that depression, which duloxetine is used to treat, may cause weight gain. So you may have weight loss after you start taking duloxetine to treat depression.

The recommended Cymbalta dosage for treating fibromyalgia or long-term pain in the muscles, bones, or joints in adults is 60 mg once per day. But if you have one of these conditions, your doctor will likely start you on 30 mg once per day. If you’re doing well on this dose, your doctor may increase your dose to 60 mg once per https://sober-home.org/how-long-does-ecstasy-last/ day. Taking these drugs with duloxetine may increase your risk of serotonin syndrome, which can be fatal. If you take any of these drugs, your doctor will start you on a lowered dosage of duloxetine and monitor you for signs of serotonin syndrome. Symptoms can include agitation, sweating, muscle twitches, and confusion.

Cymbalta may cause withdrawal symptoms if the drug is stopped suddenly. Withdrawal symptoms are side effects that can occur when you stop taking a drug that your body has become dependent on. To help make sure you do not miss a dose, try using a medication reminder.

This could be a sign the drug is working to treat your condition, meaning weight loss may not be a side effect of the drug itself. Keep in mind that conditions such as major depressive disorder, which this drug is used to treat, can also cause sexual side effects. So it may be hard for you to tell if these side effects are caused by duloxetine or the condition you’re taking the drug to treat.

An interaction is when a substance changes the way a drug works. RxList does not provide medical advice, diagnosis or treatment. Biotransformation and disposition of duloxetine in humans have been determined following oral administration of 14C-labeled duloxetine.